Molecular Genetics and Biology of Dementia
Molecular biological research has considerably deepened our understanding of the pathophysiological basis of Alzheimer's dementia. Considerable progress has been made in our understanding of the genetics and molecular biology of dementia. Some genetic risk factors have been identified so far, but only a small proportion of AD cases can be explained by specific gene mutations. Genes may be related to disease in two ways: through autosomal-dominant mutations, in themselves sufficient to cause the disease alternatively, gene variations (polymorphisms) may indirectly increase disease risk without being sufficient in themselves to cause the disorder.